- Title
- Meta-analysis: the epidemiology of noncardiac chest pain in the community
- Creator
- Ford, A. C.; Suares, N. C.; Talley, Nicholas J.
- Relation
- Alimentary Pharmacology & Therapeutics Vol. 34, Issue 2, p. 172-180
- Publisher Link
- http://dx.doi.org/10.1111/j.1365-2036.2011.04702.x
- Publisher
- Wiley-Blackwell Publishing
- Resource Type
- journal article
- Date
- 2011
- Description
- Background: Prevalence of, and risk factors for, noncardiac chest pain in the community have not been well studied. Aims: To conduct a systematic review and meta-analysis to examine these issues. Methods: MEDLINE, EMBASE and EMBASE Classic were searched (up to March 2011) to identify population-based studies reporting prevalence of noncardiac chest pain in adults (≥15 years) according to self-report, questionnaire or specific symptom-based criteria. Prevalence of noncardiac chest pain was extracted for all studies, and according to study location and certain other characteristics including presence or absence of gastro-oesophageal reflux disease (GERD) symptoms, where reported. Pooled prevalence overall, as well as odds ratios (OR), with 95% confidence intervals (CIs) were calculated. Results: Of 18 articles evaluated, 16 reported prevalence of noncardiac chest pain in 14 separate populations, containing 24 849 subjects. Pooled prevalence of noncardiac chest pain in all studies was 13% (95% CI 9–16). The prevalence of noncardiac chest pain was higher in Australian studies and in studies using a questionnaire to define its presence, compared with those using Rome I or II criteria. Prevalence was no different in women vs. men (OR 0.99; 95% CI 0.82–1.20). The prevalence was markedly higher in subjects who also reported GERD (OR 4.71; 95% CI 3.32–6.70) and increased according to frequency of GERD symptoms. Conclusions: Pooled prevalence of noncardiac chest pain in the community was 13%, but there were few studies. Rates did not appear to differ according to gender or age. Presence of GERD was strongly associated with noncardiac chest pain.
- Subject
- noncardiac chest pain; gastro-oesophageal reflux disease (GERD); risk factors; population-based studies
- Identifier
- http://hdl.handle.net/1959.13/936677
- Identifier
- uon:12375
- Identifier
- ISSN:0269-2813
- Language
- eng
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